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New Algorithm shows dopamine agonists are no longer first line treatment for RLS



The new Mayo Clinic Algorithm (2021) makes it clear that dopamine agonists are no longer first line treatment for RLS because of the high risk of Impulse Control Disorder (ICD) and augmentation of RLS symptoms. We have now updated our guidance on Augmentation and Rebound - details can be found by clicking on the ABOUT RLS tab at the top of this page.


If you are still taking dopamine agonists (Ropinirole, Pramipexole or Rotigotine (known as the Neupro patch ) keep the dose as low as possible as this may delay augmentation.


It is also important that you ask your GP for regular 3 monthly reviews of your medication to check for signs of ICD and augmentation and that your GP checks your bloods to ensure your serum iron and serum ferritin are above the recommended levels in the Mayo algorithm.

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